Product ID R3205Cas No. 36791-04-5Purity ≥98%
  • Description
  • Product Info
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  • Downloads
  • References

Description

Ribavirin is a purine nucleoside derivative that exhibits antiviral and anti-inflammatory activities. This compound displays broad spectrum antiviral activity but is most often clinically used in conjunction with IFN to treat hepatitis C infection. In macrophages, ribavirin decreases NO levels.

Product Info

Cas No.PurityFormulaFormula Wt.Chemical NameIUPAC NameSynonymMelting PointSolubilityAppearance

36791-04-5

≥98%

C8H12N4O5

244.21

1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

Copegus; Ribamidil; RTCA; Varazid; Virazole

166-168°C

Soluble in water.

White Crystal Powder

Shipping and Storage

Store TempShip Temp

4°C

Ambient

Downloads

Info Sheet

R3205 Info Sheet PDF

References

Pinilla-Macua I, Fernández-Calotti P, Pérez-Del-Pulgar S, et al. Ribavirin Uptake into Human Hepatocyte HHL5 Cells Is Enhanced by Interferon-α via up-Regulation of the Human Concentrative Nucleoside Transporter (hCNT2). Mol Pharm. 2014 Sep 2;11(9):3223-30. PMID: 24957263.

Parekh PJ, Shiffman ML. The role of interferon in the new era of hepatitis C treatments. Expert Rev Gastroenterol Hepatol. 2014 Aug;8(6):649-56. PMID: 24758387.

Wohl BM, Smith AA, Kryger MB, et al. Narrow therapeutic window of ribavirin as an inhibitor of nitric oxide synthesis is broadened by macromolecular prodrugs. Biomacromolecules. 2013 Nov 11;14(11):3916-26. PMID: 24156371.